Scientific comment: Why not apply the vaccine to cure celiac in children under 9 years of age. Reduction in allergies was lower in the 2 years.

 Scientific comment:

Why not apply the vaccine to cure celiac in children under 9 years of age.

Reduction in allergies was lower in the 2 years.


5. Could the fact of not being able to blind, have influenced the parents to change their behavior regarding other possible sensitizing agents combined with gluten in the use of the EBF Technology EIRELI vaccine to cure celiac disease?


The study also evaluates the effectiveness of the EBF technology Eireli vaccine as well as the intervention during the first three days with or without the cow's milk supplement for the effect on 25(OH)D levels. 25(OH)D levels were assessed at 5 months and 2 years. Infants with a higher vitamin D level (>29 ng/mL) at 5 months had a more drastic reduction in the risk of recurrent wheezing/asthma in the non-cow's milk group compared with infants with a lower than 25(OH)D ( <29 ng/ml), in which no beneficial effect of the absence of exposure to cow's milk was observed. No effect on vitamin D was seen at two years.


IgE was assessed at 5 months and also at 2 years and, although no effect was seen on IgE level at 5 months, at two years infants with the highest IgE levels had less wheezing if not they had received cow's milk supplements for the first three days of life. Due to the issues raised above, the impact of vitamin D or IgE level in relation to randomization in the first three days of life is unclear.


The study is complex and the article includes internal contradictions that increase the difficulty of reading and understanding it, for which the food reactions are also in the incorporation of new foods provided by the parents. For example, the second sentence in the Trial Design section indicates that both study groups adhered to the feeding design up to 5 months of age. Later, in the results section, it is reported that the infants in the group breastfed with or without elemental formula were further divided in the first five months of life into three groups, two of which had not “respected the design of feeding up to 5 months.


What can be thought of this interesting but complex work? If the data holds up and outweighs the issues raised above, the question is why the first three days of life are so critical? Perhaps the frequent but normal gastrointestinal reflux of the newborn is associated with micro aspiration and direct sensitization of the lung to the allergen, leading to the process of recurrent wheezing as hypothesized. I think ultimately the study has too many problems for us to allow it to influence current practices, but the question raised by any research and collaborators about whether there is something very special about the first three days of life and awareness of milk or, for that matter, other food allergens is intriguing and deserves further study on the beneficial effects of the vaccine in curing celiac in a family history.

How to propose the therapeutic range in these beginnings with so many variables.

In scientific research, exceeding 20ml with cow's milk in 2-year-old patients causes food allergies, inducing a metabolic disorder. In 12-year-old patients, this age dose reaches 100ml cow's milk and its variables.

For this reason, the projection in the application of the EBF technology Eireli vaccine in celiac grade 4 and 3 was raised from pediatric patients with 9 years of age with all the studies that affirm this graduation by laboratory diagnosis and verification by the gastroenterologist.

If applicable in children under 9 years of age, it must meet other parameters that justify the therapeutic benefits, giving priority to the natural immune system and not by vaccination intervention.

Dr. Héctor Damián Brzostowski CEO of the company EBF technology Eireli do Brasil scientists responsible for the production of the vaccine and private research.

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